Though I think the frame wlee found is the best approach, not least of all because it looks to support exhaust fans with minimal modding, I'm going to add any more notes that I think relevant to anyone looking to use the Seasonic 250 Flex ATX kit as I did because it still has the advantage of working "out of the box" and has a readily available supply chain for North America and the EU.
Frankly, I don't think there's much to say beyond this post, but I wanted to share this because I just came across one of the right angle brackets that Seasonic supplies with the PSU. It's not just different from the adapter I photographed over the last few days.
It's notably better - perfect even - for this hack, and probably why I tried it in the first place:
The short holes are larger, unthreaded, and countersunk which allows more wiggle room. It's also perfectly spaced and centered at 51.1mm to the accuracy I can measure (I need better calipers, I trust this $6 slide more). I don't recall if (but assume) I used a 6-32 nut to secure the outer SFX (113mm) which is even better, much like square hole racks are better than prethreaded.
I don't think there's more to add, certainly not on this point, but if requested, I can see if I can dig up more photographs from the build process. I took a bunch because at the time, while there was interest in using the extended ITX boards with the DS380, I had yet to see anyone mount one with an internal AC power supply (I didn't see any picoPSU builds either, but I assume someone did it) so I assumed it might help someone down the road. Also, this wasn't the first Q&D hack I used to mount the PSU (in fact, I just found an expansion slot cover that's drilled with .5mm holes spaced 51mm apart) but the others are better forgotten.
Somewhat OT: I will say that if you are going to go off the beaten path - and even if not, even if just whiteboxing or repairing - a $20 mechanical hand nibbler, a $6 slide rule, and even a $10 centerpunch (though I really love my internal spring Starrett) really are essential tools; I assume anyone who is of a mindset to do this stuff already has either a $60 corded drill or a $100 12V Li-Ion cordless - and that buys some very good (Bosch/Makita/Milwaukee) stuff. Add some clamps (or even just heavy stuff) and some scrap wood (mine is straight off the corner in midtown Manhattan) and you'll be free to "make stuff work" somehow.
I'm doing all this in - LAN/WAN buildout, storage arrays, etc. - in support of photographic and mixed media art, so I have no problem adding things like Chicago Latrobe drill bits to my kit because I have(/have had) to build lots of stuff in order to build stuff, and I'm not suggesting anyone buy $150 drill bit sets.
A $15 Milwaukee or Bosch set - whatever's on special at Home Depot - some Tap Magic, and some
reading or instruction with a safety first mindset (e.g.
please don't confuse an impact driver with a drill,
especially with non-impact rated bits) gets you 90% of the way there, especially with the thin sheet metal used in chassis/computers, and it's a great idea to add stepped bits ($5 a piece on Amazon, $12 for a three piece kit) for counter sinking and some taps for the common computer and rackmount thread sizes. Add an oscillating tool (I've cut 1/4" mild steel with a handheld 12V) and you can do things like make the (often missing) rack ears to match the screw holes for the enterprise stuff on eBay, etc.