I got this card last week and set it up in my HPE ML30 Gen9, running ESXi 6.5 U3. I have Plex running in an Ubuntu 18.04 VM. This card works great for hardware encode and decode (for those who haven't looked recently, note that Plex started supporting hardware decode as well on Linux starting around August 2019). I did a bit of research online on how to setup Plex for hardware transcoding, which gets trickier when dealing with a hypervisor (ESXi). It turns out that most of what I've read online that folks have had to do to get hardware transcoding working for them wasn't necessary when I setup this card on my system. It turned out to be easier than I anticipated. I think using a Quadro card instead of a desktop type card makes things simpler, using the P2200 itself made things more simple too. In addition, IMO using Ubuntu instead of Windows made configuration simpler (at least from the perspective of folks comfortable with Linux) - no need for connecting a monitor or a dummy monitor plug.
Note that the P2000 and P2200 Quadro cards are the "lowest" P-series Quadro cards that officially support an unlimited number of streams. The P2200 is slightly newer (and generally faster) than the P2000, and its street price was about the same, or when I looked, even cheaper than the P2000. Cards lower than the P2000 support a maximum of 2 streams. Likewise, desktop cards only support 2 streams. There are driver hacks available to bypass the 2 stream Nvidia driver limit, but with the P2200, there is no need for the driver hack.
So far, Plex transcoding is working well with the P2200. Even VC-1 encoded videos (which are single-threaded in CPU) work well with very little CPU impact when used with the P2200.
EDIT: I think this card works well for what it's targeted for (at least for my use as a server GPU for transcoding on a server, not desktop). Single slot, relatively cool and quiet. There's good deals to be had if you look hard online. Some may compare this to gaming desktop GPUs, but I don't think that's what this card is intended to be up against. For other use such as gaming, I use an RTX 2080 in my gaming desktop (which I wouldn't put in an ESXi server).
