No, you don't need a Quadro per-se - but I would not discount buying this particular Quadro - for an application in a very specific thermal/size envelope (single slot card that fits in a small form factor, with a thin fan and doesn't require an external power connector), this is actually rather competitive. I mean, just look at what you couldn't do with a Radeon Pro WX4100. I don't see any AMD cards out there that will come close to the performance of this card, and only use up 75 Watts TDP. It's so easy to say that if power/slot count isn't a factor, there are tons of things that would do a better job and cheaper. But then it's just a shopping exercise, not an engineering challenge.None have 4 x 4K. But the main point is, for Plex transcoding, you really DON'T need a quadro.
I hope there is a vendor out there who would put a Geforce GTX 1050 mobile on a PCIe x16 SFF card (like what happened almost 20 years ago with S3 SavageMX laptop GPUs that found its way into budget gaming cards) - this Quadro P2200 looks like a 1050 Mobile with some tweaked drivers and some nVidia artificial restriction ridiculousness lifted. You could buy one of those Eurocom MXM card + adapters - but you'll end up paying double and more for something more kludgey.