I've got a fully loaded E3 MicroCloud. It's pretty freaking awesome. Downsides to these over a traditional blade enclosure:
1) Cable management is a beast. The only shared bus is power, so you've got cables out the wazoo connected to the rear, and removing a single blade can be a chore.
2) No integrated switch. You'll need traditional network infrastructure.
3) Compared to traditional height/width blades, you only have a single PCIe slot. Do you want Infiniband? SFF-8644? An x8 M.2 adapter? Phi? Better choose, you only get one.
Aside from that, it's typical SuperMicro awesomeness. Available SATA port for a SuperDOM or similar. Internal USB if you want to boot off a thumb drive. Quality components. Low fan noise. Decent power draw. IPMI per blade. Excellent airflow design. I spent a fortune on mine new years ago, and don't regret it at all.