Chassis is plenty for that much heat. It supports dual socket boards and Supermicro sold some barebones that way. I own one myself and have used it for about 4 years now. There's a version that has 3 fans as well.
Any given platform, 1U, 2U etc has design criteria such as what CPU's to use.
Yes the motherboard can handle any Xeon processor, but typically they do not put high core count processors like a E5-2699 v4 on a dual socket motherboard in a 1U case. You might have to dig a bit but many have a list of certified parts for a given platform.
Even tho you might install higher CFM fans, better heat sinks etc heat damage can happen to the motherboard. Another case would be the processor throttles down to keep it in design TDP limits.
From experience, going with very high CFM fans like Deltas, does not mean better cooling. Air flow can be to fast to exchange heat in an efficient manor.