depends on what you're shipping and you need to spend some time doing your own research on the options. ebay's system does make it pretty easy to handle shipping, but there are many options. for small items, it's pretty straight forward and you can use their calculator by entering weight and dimensions. for larger items, or heavier items, it gets more complicated. Also, if you're selling in quantity, their quantity calculator is often wrong, so be cautious about that.
another thing to keep in mind is, i would NOT sell a single high value item on ebay if you're not a business. eBay always sides with the buyer and there's a lot of fraud that goes on in eBay. a friend of mine sold a collectable Lego set he had from many years ago. he needed some cash so he decided to sell it since it was selling on eBay for a good price. the buyer claims he received a box with filler and no lego set and opened a dispute; eBay sided with the buyer and my friend was out of his collectable Lego set and had to refund the buyer and was also out the shipping costs. as a business, if you're selling many of the same product, you can probably take the loss as a cost of doing business, but if you're selling your collectables from your attic that you only have 1 of, it's probably not a great place to do that sort of thing.
also, regarding fees... there are ways to reduce your fees. if you've got a lot of things to sell, opening up an ebay store may work in your favor. opening an ebay store automatically reduces your fees, but you pay a monthly fee to maintain the store. so you have to work out if your savings in reduced fees will be more or less than the cost of maintaining the ebay store. if you sell a lot, it usually works out to open the store. once you've sold quite a few things and have a good rating, you can also get additional discounts.