Looks like at least a part of my problem is faulty HDD, today i replaced it:
scan: resilver in progress since Tue Aug 7 17:11:22 2018
11.4T scanned
569G resilvered at 769M/s, 39.10% done, 2h37m to go
All disk showing high busy rate during scrubbing and resilvering. In past scrubbing goes at 25M/s speed and took few days to complete.
c0t50014EE2614FDB0Fd r: 1547, wr: 14, w: 0%, b: 61%
c0t5000CCA25DDFAB60d r: 3120, wr: 12, w: 0%, b: 27%
c0t50014EE2061E4C7Ed r: 702, wr: 14, w: 0%, b: 79%
c0t50014EE6598D7D63d r: 1599, wr: 12, w: 0%, b: 60%
c0t50014EE2B0E01F06d r: 1288, wr: 13, w: 0%, b: 72%
c0t50014EE0585C2728d r: 1534, wr: 12, w: 0%, b: 66%
c0t50014EE0ADB0FC2Ed r: 481, wr: 12, w: 0%, b: 84%
c0t5000CCA269D4CEB3d r: 0, wr: 1862, w: 0%, b: 88%
I will try some casual tests with huge file transfers over network after.