Not too well...asymmetric hexa-channel
Assuming you populate 8 identical DIMMs per CPU, you get actual hexa-channel for the lower 3/4 of the memory. Memory allocated in the remaining 1/4 has lower bandwidth. Only do this if you know that your applications are not memory-bound and you need a total amount of memory that can not be created with 6 DIMMs
My take is that these boards were put out there simply for convenience of those used to 4 or 8 DIMM slots per CPU. From a performance standpoint, they make no sense.
Edit: judging by the suboptimal memory configurations many system vendors tried to sell when Skylake-SP was introduced, the Idea that the memory amount has to be a power of two won't go away before Intel switches to octa-channel memory.