Here's the important thing, get standard 1500 mtu working first THEN come back and optimize. To not silo/isolate yourself it's easier w/ dedicated nics for stg/IP SAN/NAS traffic but if your sharing nics (especially for ESXi mgmt traffic) you MUST ensure you get jumbo configured properly END-TO-END and proper vlan trunk/tags assigned and cooresponding vSwitch/port group/port-profile setup to match. For jumbo mtu you gotta hit Phys switch (could be global config, per interface/vlan etc...consult your switch documentation or let me know what it is and I may be able to help), virtual switch, vmkernel port, and guest-OS if you intend to use it to that level. For simple stg you can stop one hop up.
But yeah start simple/KISS principle, then tune/tweak to hearts content.
EDIT: Ohh and BTW, save yourself some pain and don't EVEN mess w/ jumbo if you don't have a 10G network. Not worth it for nominal gains at 1Gbps v.s. complexity/additional configs tradeoffs. W/ 10G and up...ESSENTIAL!