Well my nodes would rather be based on normal workstation motherboards, for example ASRock E2PC602. I won't be using dozens of them like you do, so volume or density is not much of an issue.
I'm most concerned with residual hardware value, reusability for other purposes (web hosting), reliability, power use, and cost. Most of these factors lead me to server hardware.
Density is a bonus, but not a focus of mine. I do also like to stick to what I know, which also leans me towards server hardware primarily.
Also on cost, not all the server hardware is expensive. 2U Chassis + 2 nodes (motherboards) + 2x platinum PSUs + rails for $330 shipped or less. Add cpus, ram, and a usb stick, and its just over $1000 for a pair of dual e5-2680v2 miners in 2u. Due to larger 2u heatsinks, 80mm fans, and sharing a psu with 2 nodes, power efficiency is pretty good as well.
Not really sure how I would propose to save money using crappier gear at that price point. Even if I could save a couple bucks, seems like a false economy.
edit: I would say, the above is unlikely to work with GPUs. For my GPU builds, the server grade hardware is quite a bit more expensive. Workstation boards may be a better choice in that scenario.