Since this is a home lab/media server/fileserver/backup storage I'm always tinkering with it. In fact, tinkering with it is the whole point. There is nothing critical that's not backed up regularly and in multiple places. For data I truly care about I have a backup strategy that would make even the most paranoid hoarder shake his head.
I'm not very likely to pull the wrong drive but the chances of that, or a loose cable, are much higher than the .1-.3% annual failure rate that STH has seen with used data center SSDs. However I manage pooling the drives it needs to protect me from myself. Since it's all flash, I don't need striping for performance and I'm convinced that parity is a waste of space in this application. JBOD pooling + iSCSI and smb + checksumming + ability to temporarily lose a drive would be a winner.
sorry I am in totally different state of mind when it comes to tinkering
for me it is just a necessity not the point of it. once I have a setup I like I usually go with hands-off approach.
my first home server was an UnRaid setup on a DIY white box. once it was up I run it for 3 years only login onto it for small updates and to make new folder.
as soon as I am satisfied with my new server setup, it will be the same way.
right now, I am running OMV as main OS. raid-1 on 2 SSDs for System drive
I have 8 or 10 mixed drives, some 3TB, some 2TB couple of 1GB all individually formatted with BTRFS (this gives me CoW and bit-rot protection for data)
run SnapRaid in raid-6 config on all data drives (2x3TB drives are reserved for Parity, rest is data)
and MergerFS to pool the drives into single share.
I use NFS and Samba for sharing folders on MergerFS volume, it is not advisable to share the root on the pool.
I guess you can add iSCSI to the mix as well
the beauty of this setup is that all drives are totally independant of each other.
I can pull drive out and use it in other system if I need to, and as long as I put it back before the scheduled SnapRaid scan I will not have an issue, and even if I miss the scan, SnapRaid will usually correct the error when the drive is back.
MergerFS will show you error about missing disk but will still work. all data on other drives are still accessible, only data stored on missing drive is not.