Did a test with a 100 GB file. On each PC one NIC is idling and the other one is at 99 % according to the Task Manager, at the LACP connection between the switches it's the same although the activity monitor of the mentioned
TP-Link TL-SG2210P seems to be buggy, one connection is at 0.00 % the other one at 0.17 % (at 118 MB/s).
Just to clarify, both PCs have two NICs that are not teamed together (LACP'ed or other), correct? And you're
sure the ports on the switches the NICs are connected to
are not configured for LACP, only the LACP between the switches is configured?
@PigLover's suggestion is what I'd try next too: Confirm you can get SMB Multipath working with both machines plugged into
the same switch. Next, confirm it still works (albeit slower) with only one 1GbE link between the switches and LACP disabled. Than scale back up to your LACP configuration. Removing as many variables as possible is the only way to get to the bottom of this stuff sometimes.