A quick update - after losing some hair trying to get the W7100 to work (which I thought it would as its Tonga, same as the S7150's) I spotted a cheap(ish) S7150 and went for it. I have since learned a lot more about Vcenter, how to install, configure and add plug in's for Radeon Pro.
I'd only ever used the ESXI web client before, so at the end of the day some valuable learning time, if a bit frustrating.
Anyways, I now have the ability to assign a GPU to several VM's (I've got 2 Win 10 for CAD use with MxGPU and one Win10 for general purpose with SVGA) and can manipulate large 3D CAD models smoothly, I think I still need to fine tune something somewhere as realistic rendering time is not great, might have to assign more CPU to the VM? also live video streaming via Synology Surveillance station is poor and drags the system down, but the cameras streaming direct to a browser is fine...
The one caveat is the power that the S7150 uses while assigned to VM's it'll use an extra 50-100W whilst assigned to a couple VM's, I'm hoping with some further investigation there might be a way to control power usage better. It also runs quite hot with an outer surface temp of 70+DegC, this is with a Gentle Typhoon blowing along it.
So, ultimately only a minor improvement on total power usage, with the Workstation being relegated to a corner of the room, but a much tidier desk!
At some point I may try to re-visit the W7100 when I feel the need of a challenge again! It just did not want to work with Horizon view for some reason, passing through to the VM always worked.
BTW I managed to get round the fan wall problem (luckily it was only fixed in with screws, so could re-position it approx. 20mm from the rear of the card.
Thanks to all who provided some pointers...