I've also fit SSI-EEB boards in the old Enthoo Pro, missing a few standoffs but no problems. But any large tower case may have issues with VRM cooling as the VRM heatsinks aren't terribly big, and the large case provides lots of space for the air to avoid the VRM heatsinks. If you feel inspired you might experiment with fashioning a shroud to divert some air directly through the VRM heatsinks (whilst keeping sufficient air for the rest of the components, of course).
This sounds like an interesting project. I have experimented a bit with a CPU shroud on a Threadripper machine (Thelio Major).
Here are some results I obtained from testing an H11DSi + 2x7f52 machine (258GB RAM) in a Dark Base Pro 900 case with three 1000rpm front fans, one 1000rpm back fan and Noctua NH-U14S coolers with 1500rpm fans blowing upwards:
stress-ng —cpu 30 —vm 30 —vm-bytes 75%
————————————————————————-
Test Duration: 4 hours
CPU: 60C, 63C
VRMCPU: 69C, 69C
VRMSoc: 57C, 67C
VRMHA…: 64C, 80C, 74C, 59C
DIMM’s: 49-65C
stress-ng (max cpu’s)
————————————
Test Duration: 2 hours
CPU: 61C, 61C
VRMCPU: 72C, 72C
VRMSoc: 50C, 54C
VRMHA…: 53C, 66C, 54C, 47C
DIMM’s: 38-49C
Temperature were obtained from ipmitool sensors.
Ambient Temperature was around 71F.
Feel free to comment on wether you think additional cooling is needed.