Looks nice! If you have a rack to mount it (pun not intended) and have a dozen DDR4 RAM sticks laying around, I'd say go for it! Those beefy PCIe switches look nice!
I have a Rack to mount it but it's a bit wasted to be honest (I should have a few Units left, but I wasn't really planning on adding 2x4U extra).
I'm mainly concerned about the noise though and how it can be controlled though. Also not sure about Rails availability.
RAM I can get (still have a few I could transfer) pretty cheap. I would probably go for 24x32GB = 768GB

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Gigabyte's G292 line used to be quite cheap when it first hit ebay but then the AI bubble started soon after and prices shot up a lot. It's a nifty 2U unit that can also host eight dual slot GPUs, perfect for Mi50s.
Gigabyte's G292 ... for 8 (not 4 ???) dual Slot GPUs



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Two GPUs are pretty easy with many LGA3647/LGA4189/SP bards. Some let you do up to four (SPC621D8, X11SPA, X11SPL, MU71-SU0). Basically, if the board has seven PCIe slots (as long as each is at least Gen 3 X4) you can install four dual slot cards like the Mi50 without risers.
On Supermicro X9/X10 Series for Xeon E5 v2/v3/v4 (not sure about X11 Series for Xeon Scalable) the last PCIe Slot is Typically a PCH (Chipset) connected Slot which is only 2.0 x4 (yes, PCIe 2.0 - YIKES).
Then finding the right Chassis might be the Challange ... I usually go for the Fractal Define Series but the R5/R6 has only 7xPCIe Slots (I would need 8x since 4xdual Slot, the R6 has 2x extra with a Riser though). Looks like I might need to go to some uncharted Territory for me. Something like the Fractal Design Meshify 2 XL has 9xPCIe Slots so it could fit the Bill. The Fractal Design Define 7 XL of course would also work but it's probably more expensive (9 x PCIe Slots + 3 x PCIe Slots with Riser).
Plus at those Prices (cheapest is around 400 EUR from China) ... wouldn't it just be better to get an AMD EPYC 7002 Series System based on Supermicro H11SSL-i Version 2 from China, should be around 500-600 EUR including CPU.
Too bad there is no easy way to "bring out" a PCIe x16 Slot (Bifurcation NOT possible) from the
HYVE Server that I have. It would require a PCIe Active Adapter (to either 4xU.2 or 4xM.2), around 150-200 EUR, plus some Oculink Cables going somewhere out of the System to another Chassis, then a "standard" SFF-8643 to PCIe x16 Adapter such as this one:
Probably at the very least around 300 EUR plus Oculink SFF-8611/SFF-8612 Cables. Not sure if it's really worth it at that Point though.
Other Ideas ?
Feel free to PM me about the X10DRX or if you have other Boards for Sale BTW

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EDIT 1: the Supermicro H11SSL-i indeed would be limited to 3xGPUs without Risers, so that's probably not an Option

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