I have a TrueNAS Scale box with a 12600K (6P4E), though it's primarily a virtualization and container server plus some backup for my main Core box. I haven't noticed anything funny in terms of performance; I'm running a Windows 11 gaming VM with 5 cores/10 threads allocated and everything's been scheduled onto the appropriate cores. One minor thing is the Alder Lake iGPU isn't supported out-of-the-box but it's pretty trivial to enable it.
Anything in particular you'd like tested out?