I would say that depends on density, price/tb, space in your 'datacenter' and connectivity cost (initial and running)...I believe 2.5 drives are not useful for farming but only for plotting. That might be something to consider. How much are they asking for Ds4246?
I plan to convert my 40 900g drives which are on plotting duty to storage when I am done... o/c its easier to use 2 18t drives, but I am sure the 40 2.5" are cheaper (even when considering running costs for a few months)