I have this motherboard, and like the rest of my Supermicro kit it runs like a top ... what are your concerns ?
The C606 variant of this board is the
X9DR3-LN4F+, which gives you 8x SAS ports from the C606 chipset compared to 4x SATA ports from the C602 chipset. I believe the same "bare board" is used for both the "i" and "3" variants.
In terms of form factor, the "+" in the product name indicates it's a board that supports 24x memory slots, so it becomes a "wide" form factor. The page that you linked has recommended 2U, 3U and 4U/Tower supermicro chassis. If you want to run GPU's then you are likely looking at the 4U/Tower chassis.
I have not run this motherboard in anything other than a SM chassis, so I can't provide guidance as to a compatible non-SM chassis. I do think that it is a "non standard" form factor though.
If you don't need the 24x memory slots then the X9DRi-F is the more standard E-ATX form factor with 16x memory slots. Still the C602 chipset, but you drop one x16 pcie slot from 4 to 3, and you move from a square to narrow ILM CPU cooler footprint.