it totally depends on what you are doing. and how many files you have. and how big they are.
I have a tool here that I wish I could share that give me the file size histograms that I use to make that determination.
50 TB uses 16K sector sizes. so if you have large files you can do that. if you have small files, you should brak it up in to 3-4 smaller partitions. also if you need to backup the 50 TB... you need to consider VSS snapshot sizes. if you plan on having a greater than 64TB volume, you should format the volume with 32 or 64K sector size.
If you have a lot of small/medium files. CHKDSK can take days to weeks to complete on a corrupted volume.
You still have the file limitations of NTFS.
NTFS - Wikipedia
Chris
and yes, I have way TOOO much experience with NTFS...