I thought it would be a good idea to write a follow up If some one else finds this thread:
The entire rack had been shut off for a couple of days. After powering everything back on, strange problems appeared immediately. The most serious being random lost connections to datastores on all hosts (esx.problem.vmfs.heartbeat.timedout), along with slow read/write performance. After extensive troubleshooting I started to suspect that maybe I did start to configure DCB and forgot to save the config prior to shutdown. So I added these lines to the configuration.
Bash:
# Global switch config
dcb priority-flow-control enable
dcb priority-flow-control priority 3 enable
# On interfaces
interface ethernet x/x
dcb priority-flow-control mode on
Now the r/w performance is good again and so far (knock on wood) there are no datastore connection losses.
@kapone