I'm passing a 7750 and a Quadro P4000 and a 2200 with an Highpoint usb car and a single 2 port renessa usb card. All pass wonderfully. But best performance are with a 4vcpu max and efficient with 9g of ram on gaming vm. 9 or 12g, no diff really on the fps. And got other linux web surf and nas server all running as well.