Feels like its not worth going older than the D2143it from the cheap
dattos like this one for the xeon D series (comes with
this mobo).
Depends on your use case, your stash of old parts and what you are planning to replace. The Epyc 3151 is probably a good board to replace a board with a Haswell Xeon (say, like an E5 1230v3) or a low wattage Skylake Xeon (any of the Xeon Bronze 3000s or like a 1260L v5).
This is prefaced with “if you have idle DDR4 server RAM modules and storage just sitting around wasting space”.
@Patrick did make a case study out of the Dell EMC VEP4600, which is 500 bucks for an entire working machine with 64GB of DDR4 server RAM. That 16 core, 32 thread D2187NT chews up about 110 watts of power but is roughly the same performance ballpark as the 8 core, 16 thread Ryzen 7 6850U pulling 28w on an HP Elitebook 845 G9. Of course, getting 64GB (2x32GB) DDR5 SODIMM for that 845G9 will probably cost at least 700 today (it was about 225 in early 2025), but hey, that VEP4600 can do, what, 256GB maxed out on 32GB DIMMs? That's nothing to sneeze at for a home lab and the power draw will take a while to match/exceed the pricing on something more modern, even when the power efficiency is factored in.