Isn't the limiting factor for U2 density the heat? The chassis cages don't worry about that due to the airplane fans driving air through but pretty sure if you're planning to pack 5.25" slots with it you'll have to solve the big cooling problem at the same time.
3000 per single point of failure isn't really a realistic example though. looking to upgrade a ceph cluster that has 6x1.92tb hgst per c6220 node.
of course willing to consider other high density chassis with u2 bays that is reasonably priced compared to just refitting them with higher capacity...
you can fit 4x m2 per pcie slot with the hyper m2 but i've not seen any adapter that takes more than 2x u2 (trying to fit drives into high density rack servers like c6220)
Those are slot heavy though. With the m2s you could stick 4 of them on a single x16 slot with the hyper m2 or just use regular 2.5" bays with the SATAs
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