nope, server boards are mostly (99,9%) very conservative about any type of overclocking (cpu, memory, timings etc etc).
i know you talk about optimizing/tweaking, but that is also overclocking.
so, short answer to your question: no, not on server platform. why ? my guess: overclocking can give you some unstable machine, this is what you don't want in server enviroment.
but....for example mining monero coin with your cpu's....sometimes you get higher moner-hashrate if you disable CACHE PREFETCH. this is something you can disable in epyc-bios (unmodded bios). this way you can get little bi higher hashrate for monero. but this is not a real "tweaking", comparable to desktop-bios's. because in dekstop-bios you can also disable/enable CACH PREFETCH.
but (2nd time)......what program or software are you using ?? any specific name ??
maybe then you can profit from changing some bios settings.
once again...server platform (epyc) is desinged for stability...not for overclocking/optimizing.....
i have dual epyc 7551 system....i can run some benchmarks for you if you want that